To the Editor.—
A few clinical observations suggest that the loss of sympathetic innervation may result in changes in pigmentation of the skin and hair.1 In our patient, the development of gray hair with age was retarded on the denervated side after lumbar sympathectomy.
Report of a Case.—
At the age of 46 years, a man had a right lumbar sympathectomy at the level of the fourth lumbar ganglion. He was seen again at the age of 76 years. The patient had noticed a difference in the pigmentation of his pubic hair three or four years before his latest office visit. No depigmenting agent had been previously used to account for this pigmentary disturbance. He did not recall any unilateral inflammatory lesions that might have caused postinflammatory hypopigmentation. This patient also suffered from psoriasis, which was in remission. On examination, the patient's scalp hair was uniformly gray. However, the
Ortonne J, Thivolet J, Guillet R. Graying of Hair With Age and Sympathectomy. Arch Dermatol. 1982;118(11):876-877. doi:10.1001/archderm.1982.01650230004005