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November 1982

High-Dose Vitamin A Therapy for Darier's Disease

Author Affiliations

From the Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Dermatol. 1982;118(11):891-894. doi:10.1001/archderm.1982.01650230019019

• Three patients with Darier's disease were treated with 1 × 106 IU of orally administered vitamin A daily for 14 days. In all patients, 50% to 80% improvement in the skin lesions was noted. Desquamation was minimal, and side effects consisted of drowsiness, mild frontal headache, dry lips, and dry nose. During therapy, all patients had a transient, mild increase in the serum triglyceride level, and two patients had a minimal increase in the serum cholesterol concentration.

(Arch Dermatol 1982;118:891-894)