• Three patients with Darier's disease were treated with 1 × 106 IU of orally administered vitamin A daily for 14 days. In all patients, 50% to 80% improvement in the skin lesions was noted. Desquamation was minimal, and side effects consisted of drowsiness, mild frontal headache, dry lips, and dry nose. During therapy, all patients had a transient, mild increase in the serum triglyceride level, and two patients had a minimal increase in the serum cholesterol concentration.
(Arch Dermatol 1982;118:891-894)
Thomas JR, Cooke JP, Winkelmann RK. High-Dose Vitamin A Therapy for Darier's Disease. Arch Dermatol. 1982;118(11):891-894. doi:10.1001/archderm.1982.01650230019019