† A dramatic alteration from clinically subpolar tuberculoid leprosy toward subpolar lepromatous leprosy was observed during griseofulvin therapy in a 29-year-old man, despite apparently normal cell-mediated immunity. To our knowledge, this is the first reported case of a downgrading reaction associated with griseofulvin. It is possible that this reaction was due to inhibition of polymorphonuclear leukocyte chemotaxis by griseofulvin.
(Arch Dermatol 1982;118:909-912)
Shulman DG, Wilkinson RD, Nguyen N. Leprosy Downgrading Reaction Associated With Griseofulvin. Arch Dermatol. 1982;118(11):909-912. doi:10.1001/archderm.1982.01650230037024