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December 1982

Small Cell Carcinoma of the Lung With Leser-Trélat Sign

Author Affiliations

From the Departments of Dermatology (Dr Hattori) and Internal Medicine (Drs Umegae and Kataki), Maebashi (Japan) Red Cross Hospital; and the Pathology Division, National Cancer Center Research Institute, Tokyo (Dr Nakajima).

Arch Dermatol. 1982;118(12):1017-1018. doi:10.1001/archderm.1982.01650240061024

Leser-Trélat sign, the sudden appearance and rapid increase in size and number of seborrheic keratoses, frequently accompanied by pruritus, is considered to be indicative of an internal malignant tumor. Adenocarcinoma is the type of malignant neoplasm most commonly associated with the Leser-Trélat sign.1 Herein we report the first case, to our knowledge, in which this sign was associated with small cell carcinoma of the lung.

Report of a Case  A 72-year-old man with a three-year history of diffuse eczematous dermatitis was examined at the Maebashi (Japan) Red Cross Hospital in April 1980. His rash, involving the trunk and the extremities, was pruritic and characterized by papules, erythema, and lichenification. It responded to topical administration of 0.05% fluocinonide. In August 1980, however, the patient noticed the sudden appearance of multiple discrete, hyperpigmented, verrucous lesions on his back, shoulders, and chest (Fig 1). These lesions appeared in areas where the eczematous

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