• Progressive vaccinia developed in a previously healthy woman following smallpox vaccination and was successfully treated with vaccinia immune human globulin and methisazone. Immunologic evaluation over the next 4½ years revealed evidence for combined variable immunodeficiency with increased numbers of circulating OKT 8 positive (suppressor-cytotoxic T) cells and the virtual absence of OKT 4 positive (helper-inducer T) cells.
(Arch Dermatol 1983;119:404-408)
Keane JT, James K, Blankenship ML, Pearson RW. Progressive Vaccinia Associated With Combined Variable Immunodeficiency. Arch Dermatol. 1983;119(5):404-408. doi:10.1001/archderm.1983.01650290044015