• A 46-year-old woman had a 17-year history of intermittently severe pyoderma gangrenosum without identifiable associated systemic disease. Her condition had become unresponsive to corticosteroid and sulfone therapy given for systemic effect, but responded completely to 150 mg/day of cyclophosphamide. Immunosuppressive therapy should be considered in patients with severe, recalcitrant pyoderma gangrenosum, even in the absence of associated systemic disease.
(Arch Dermatol 1983;119:495-497)
Newell LM, Malkinson FD. Pyoderma GangrenosumResponse to Cyclophosphamide Therapy. Arch Dermatol. 1983;119(6):495-497. doi:10.1001/archderm.1983.01650300049015