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Article
July 1983

Late-Onset Chronic Mucocutaneous and Ocular Candidiasis and Malignant Thymoma

Author Affiliations

From the Departments of Dermatology (Drs Palestine and Su) and Ophthalmology (Dr Liesegang), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Dermatol. 1983;119(7):580-586. doi:10.1001/archderm.1983.01650310042009
Abstract

• Late-onset chronic mucocutaneous candidiasis (CMCC) is part of a spectrum of candidal infections. It usually develops during or after the fourth decade of life and is often associated with an underlying neoplasm, especially thymoma. A 56-year-old man with late-onset CMCC and thymoma had several unusual features. His malignant thymoma seemed to be more widespread than the thymomas of previously described patients. Ocular infection was present in addition to extensive involvement of the skin, nails, and oral mucosa. To our knowledge, this is the first report of ocular involvement in this syndrome. We also believe that this is the first patient with thymoma-associated late-onset CMCC to be treated effectively with ketoconazole.

(Arch Dermatol 1983;119:580-586)

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