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To the Editor.—
In a letter to the editor in the August Archives (1982;118:535-536), Lindskov reported the nail findings in a patient receiving the aromatic retinoid etretinate for psoriasis. We report our results with retinoid treatment in two patients who had generalized psoriasis with prominent nail involvement.
Report of Cases.—Case 1.—
A 46-year-old man had extensive plaque-type psoriasis and the following nail changes: pitting, onycholysis, crumbling of the nail plate, proximal nail-fold involvement, and oil-drop change (Fig 1). The patient was receiving 0.5 to 1 mg/kg/day of oral etretinate. In terms of nail involvement, excellent improvement was noted in the crumbling of the nail plate and oil-drop change, and the onycholysis was responding well. Psoriatic involvement of the proximal nail fold improved moderately, and a fair response in the pitting was noted (Fig 2). The systemic side effects of the experimental drug included cheilitis, hair loss, itching, dryness,
Rabinovitz HS, Scher RK, Shupack JL. Response of Psoriatic Nails to the Aromatic Retinoid Etretinate. Arch Dermatol. 1983;119(8):627-628. doi:10.1001/archderm.1983.01650320001002