• A patient with generalized granuloma annulare experienced resolution of her lesions after six months of treatment with 1,500 mg/day of niacinamide. Niacinamide seems to be a reasonably safe drug that, even at relatively high doses, is associated with a low incidence of side effects. The participation of a delayed hypersensitivity reaction in the pathogenesis of granuloma annulare and possible mechanisms involving niacinamide in this type of reaction are discussed.
(Arch Dermatol 1983;119:836-839)
Ma A, Medenica M. Response of Generalized Granuloma Annulare to High-Dose Niacinamide. Arch Dermatol. 1983;119(10):836-839. doi:10.1001/archderm.1983.01650340046018