To the Editor.—
There have been reports on hyper-pigmented freckles occurring during psoralens and UV-A therapy1,2 and epidermal dystrophy and actinic keratoses following this treatment.3 We report herein a case of xeroderma pigmentosum-like changes occurring during treatment with psoralens and UV-A.
Report of a Case.—
A 52-year-old man with skin type 3 (sometimes burn, always tan) had generalized psoriasis that had been treated with a total of 2,241 joules/sq cm during 211 sittings for 39 months. The psoralens used were those in methoxsalen, with 0.040 g (patient weight, 70 kg) swallowed two hours before the only skin irradiation by UV-A. Treatment tolerance was good, except for some erythema on the back during the first sittings. Treatment was extremely effective on psoriasis. It has been interrupted because of the noticed modifications in the appearance of the teguments (Figure). These included dry skin with little white atrophic areas, numerous black
Lorette G, Jafar R, Grojean M, Benatre A. Xeroderma Pigmentosum-like Changes. Arch Dermatol. 1983;119(11):873-874. doi:10.1001/archderm.1983.01650350001001