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November 1983

T Cells in Cutaneous Lesions of Sézary Syndrome and T-Cell LeukemiaCharacterization by Monoclonal Antibodies

Author Affiliations

From the Departments of Dermatology (Drs Buechner and Winkelmann) and Surgical Pathology (Dr Banks), Mayo Clinic and Mayo Foundation, Rochester, Minn. Dr Buechner is a visiting clinician from the Department of Dermatology, University of Basel, Switzerland.

Arch Dermatol. 1983;119(11):895-900. doi:10.1001/archderm.1983.01650350023008

• Anti—T-cell monoclonal antibodies (LEU series) immunoperoxidase technique study for the presence of T cells in cutaneous lesions from four patients with Sézary syndrome and one patient with chronic T-cell leukemia showed that most dermal-lymphoid cells from three patients with Sézary syndrome were reactive with monoclonal antibodies to anti—pan T-cell (LEU-1) and helper T-cell (LEU-3a) subsets but not with those to suppressor-cytotoxic T-cell (LEU-2a) subsets. One patient with progressive disease had atypical dermal-lymphoid cells positive for pan T-cell (LEU-1). Epidermotropic cells were reactive to LEU-1 in all four patients, LEU-2a in one patient, and LEU-3a in one patient. Neoplastic cells in skin lesions of chronic T-cell leukemia showed strong positive staining with LEU-1, but were reactive with both anti—T-cell subset, monoclonal antibodies. The atypical, dermal-lymphoid cells in Sézary syndrome represent mature, helper T cells in most cases. The absence of T-cell subset antigens in one patient with fulminant Sézary syndrome and the finding of both T-cell subset antigens on T-cell leukemia cells suggest the presence of actively proliferating, immature T cells in those cases.

(Arch Dermatol 1983;119:895-900)