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December 1983

Usefulness of Direct Immunofluorescence in Patients With Lupus Erythematosus

Author Affiliations

From the Department of Dermatology, University of Minnesota Medical School, Minneapolis.

Arch Dermatol. 1983;119(12):1010-1017. doi:10.1001/archderm.1983.01650360056014

Aseries of questions was submitted to each participant. They answered them and then reviewed and commented on the answers of the other participants. The editor, Mark V. Dahl, MD, has assembled and edited these remarks in the interest of brevity and clarity.

Archives: The presence of immunoreactants at the dermoepidermal junction (DEJ) of patients with discoid and systemic lupus erythematosus (LE) is characteristic, and the presence of a band of deposited IgG, IgM, IgA, and/or C3 is widely used to help identify patients with these diseases. While the presence of immunoreactants at the DEJ was once believed to be a finding rather unique to LE, similar deposits have been found in the involved skin of some other skin disorders. Do these findings dilute the usefulness of direct immunofluorescence microscopy of involved skin as an aid to the diagnosis of systemic LE and discoid LE?

Susanne Ullman, MD, Copenhagen: Direct immunofluorescence

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