Several cutaneous markers of internal malignancies are known. Acanthosis nigricans is characterized by velvety, pigmented elevated plaques.1 The Leser-Trélat sign involves the sudden onset and rapid increase in number and size of seborrheic keratoses, associated with severe pruritus.2 These cutaneous changes are known to occur in association with internal malignancies, especially gastrointestinal (GI) tract adenocarcinomas. Recently, the possible association of keratoacanthoma with internal malignancy has been proposed. The relationship can occur as a part of the Muir-Torre syndrome, a constellation of multiple internal malignancies, sebaceous tumors, and keratoacanthomas.3 In some patients, sebaceous tumors may be absent.4-8
We report a case of multiple keratoacanthomas that preceded the detection of cervical squamous cell carcinoma. Our patient had no lesions of sebaceous gland origin. We also compare our case with similar cases reported in the literature and propose the term keratoacanthomavisceral carcinoma syndrome.
Report of a Case
Inoshita T, Youngberg GA. Keratoacanthomas Associated With Cervical Squamous Cell Carcinoma. Arch Dermatol. 1984;120(1):123-124. doi:10.1001/archderm.1984.01650370129028