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Article
February 1984

Generalized Epidermolytic Hyperkeratosis in the Child of a Parent With Nevus Comedonicus

Author Affiliations

DC Path, MRC Path

From the Division of Dermatology, Department of Medicine (Dr Lookingbill); Division of Genetics, Department of Pediatrics (Dr Ladda); and the Department of Pathology (Dr Cohen), Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.

Arch Dermatol. 1984;120(2):223-226. doi:10.1001/archderm.1984.01650380083017
Abstract

• Nevus comedonicus (NC) is rarely associated with the histopathologic changes of epidermolytic hyperkeratosis (EH). A parent with mild focal NC had a child with severe generalized EH. The histopathologic findings of skin biopsy specimens from parent and child showed the distinctive granular and spinous layer vacuoles and coarse keratohyaline granules of EH. This parent and child may be examples of the extremes in expression of an autosomal dominant trait.

(Arch Dermatol 1984;120:223-226)

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