To the Editor.—
We report herein a case of milia following topical therapy with fluorouracil. Various side effects have been reported with this agent but, to our knowledge, this is the first description of such a reaction.
Report of a Case.—
A 72-year-old, healthy woman was referred to the outpatient clinic because of multiple facial solar keratoses. History and medical examination were unremarkable with the exception of the prior removal of a benign polyp from the gastrointestinal tract.Treatment for the keratoses was initiated with a topical 1% fluorouracil solution in propylene glycol, administered twice daily. On the eighth day of treatment the lesions became red and inflamed and clobetasol propionate was prescribed together with the fluorouracil for three weeks.
Brenner S, Shohet J, Krakowski A, Ilie B. Mucoid Milia. Arch Dermatol. 1984;120(3):300. doi:10.1001/archderm.1984.01650390022005