• Multiple cutaneous xanthomas developed in a patient at the age of 10 months, and juvenile chronic myeloid leukemia (JCML) developed at the age of 30 months. The xanthomas were histopathologically consistent with a diagnosis of juvenile xanthogranuloma (JXG). A review of other cases of JCML with JXG indicates that the cutaneous lesions have many clinical and histopathologic similarities to sporadic JXG but are more often multiple or papular and confluent. In addition to JXG, a few children with JCML also have multiple café-au-lait spots and a family history of neurofibromatosis.
(Arch Dermatol 1984;120:371-375)
Cooper PH, Frierson HF, Kayne AL, Sabio H. Association of Juvenile Xanthogranuloma With Juvenile Myeloid Leukemia. Arch Dermatol. 1984;120(3):371-375. doi:10.1001/archderm.1984.01650390093020