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Article
May 1984

Cowden's DiseaseAssociation With Squamous Cell Carcinoma of the Tongue and Perianal Basal Cell Carcinoma

Author Affiliations

From the Department of Medicine, Division of Dermatology, Ohio State University, Columbus (Drs Camisa and McDonald). Dr Bikowski is in private practice, Sewickley, Pa.

Arch Dermatol. 1984;120(5):677-678. doi:10.1001/archderm.1984.01650410121027
Abstract

The multiple hamartoma syndrome (Cowden's disease) is a rare condition with an autosomal-dominant inheritance pattern. It is characterized by multiple facial trichilemmomas, oral fibromas that give the mucous membranes a "cobblestone" appearance, and keratoses of the hands that resemble flat warts on the dorsal surfaces and arsenic keratoses on palmar skin. Cowden's disease also has a striking association with visceral disease, particularly malignant neoplasms of the breast1 and thyroid.2 We present our ten-year experience with a man who had Cowden's disease. His case was described briefly in 19773

Report of a Case  A 50-year-old man first sought dermatologic treatment in 1972 for multiple "warts" on his hands and face that had been present for approximately 30 years. He had had no family history of similar skin problems. His medical history included hypothyroid

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