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June 1984

Loss of Membrane B2 Microglobulin in Eccrine PorocarcinomaIts Association With the Histopathologic and Clinical Criteria of Malignancy

Author Affiliations

From the Department of Dermatology (Drs Holden and Mac-Donald) and the Medical Research Council Immunology Team (Dr Sanderson), Guy's Hospital, London, and the Departments of Dermatology (Dr Shaw) and Histopathology (Dr McKee), St Thomas' Hospital, London.

Arch Dermatol. 1984;120(6):732-735. doi:10.1001/archderm.1984.01650420042012

• A sensitive immunoperoxidase method employs a new chicken anti-B2-microglobulin (B2M) antibody for use on paraffin sections. The method demonstrates the loss of B2M from the cell membranes of malignant eccrine poromas, and this is correlated with the histopathologic and clinical criteria of malignancy.

(Arch Dermatol 1984;120:732-735)