• The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation.
(Arch Dermatol 1984;120:762-764)
Hashimoto K, Singer K, Lazarus GS. Penicillamine-Induced PemphigusImmunoglobulin From This Patient Induces Plasminogen Activator Synthesis by Human Epidermal Cells in Culture: Mechanism for Acantholysis in Pemphigus. Arch Dermatol. 1984;120(6):762-764. doi:10.1001/archderm.1984.01650420072019