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Article
July 1984

Granuloma Annulare Caused by Injectable Collagen

Author Affiliations

Department of Medicine and Dermatology UCLA School of Medicine Los Angeles, CA 90024

Arch Dermatol. 1984;120(7):837-838. doi:10.1001/archderm.1984.01650430023004
Abstract

To the Editor.—  Injectable collagen has been used in California for approximately five years and, in 1981, gained Food and Drug Administration approval to be used nationally.Collagen implant (Zyderm), a highly purified bovine dermal collagen, contains a small amount of xylocaine and has been used for the augmentation of certain dermal defects. Depressed surgical scars, acne pits and scars, atrophy, and aging lines have been treated in a "building-up" procedure. Several thousand patients have been treated to date. It was shown not to be an allergen in animal work. A few reported instances of localized erythema, localized swelling, and localized induration have been noted. At times, sunlight exposure or alcoholic intake were thought to be a causative factor. Test doses in the forearm are recommended before treatment. Occasional reports of urticarial reactions and other generalized

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