To the Editor.—
During the past two decades, colchicine has been shown to be effective in treating a wide variety of inflammatory disorders, including the cutaneous lesions of Behçet's disease.1 As there is no clear-cut distinction between recurrent oral ulcers or so-called aphthous stomatitis and the mucosal involvement in Behçet's disease,2 we used colchicine therapy in four cases of protracted aphthous stomatitis.
Report of Cases.—Case 1.—
A 32-year-old woman had a long history of recurrent ulceration of the mouth during every menstrual period. Following a prodromal phase of soreness and burning sensation for one to two days, two or three small aphthous ulcers appeared, causing pain for ten days. Oral colchicine, 0.6 mg/day, was administered for a month, with no recurrence of the ulcers during the subsequent menstrual period. However, the patient complained of nausea after one month of therapy, so we limited administration of the
Gatot A, Tovi F. Colchicine Therapy in Recurrent Oral Ulcers. Arch Dermatol. 1984;120(8):994. doi:10.1001/archderm.1984.01650440024010