• Two patients had facial tumors that had a distinctive microscopic appearance. Each consisted of multiple nests of glycogen-filled clear cells dispersed in the dermis and associated with a hyalinized, collagenous stroma. There were also ductular features suggestive of eccrine differentiation. The lesions had a locally infiltrative microscopic appearance, and one involved the subcutaneous fat and skeletal muscle. Although neither tumor has recurred following excision, we believe that they are low-grade eccrine carcinomas and that they may represent a distinctive, albeit rare, subtype of adnexal neoplasm.
(Arch Dermatol 1984;120:1076-1078)
Cooper PH, Robinson CR, Greer KE. Low-grade Clear Cell Eccrine Carcinoma. Arch Dermatol. 1984;120(8):1076-1078. doi:10.1001/archderm.1984.01650440106032