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Article
October 1984

Extramedullary Hematopoiesis

Author Affiliations

Division of the Biological Sciences University of Chicago Pritzker School of Medicine 5841 S Maryland Ave, Box 409 Chicago, IL 60637

Arch Dermatol. 1984;120(10):1282. doi:10.1001/archderm.1984.01650460022012
Abstract

To the Editor.—  Extramedullary hematopoiesis (EH) is a rare but specific cutaneous manifestation of myelofibrosis with myeloid metaplasia (MMM). With the exception of hemorrhagic purpuric eruptions in neonates, EH has only been described in patients with myelofibrosis.1-5 We report herein a case of EH of the skin that differs histologically from previously described cases.

Report of a Case.—  A 67-year-old woman was seen in the hematology clinic at the University of Chicago in December 1979 for evaluation of anemia and hepatosplenomegaly. A bone core biopsy disclosed changes consistent with a diagnosis of MMM. Subsequent treatment included 100 mg/day of oral oxymetholone and several hospital admissions during which the patient received a packed RBC transfusion.In October 1981, the patient was seen in the dermatology clinic with a two-month history of asymptomatic papulonodules on the thighs and trunk. Physical examination showed firm, 5-mm erythematous nodules on the medial aspect of

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