To the Editor.—
Extramedullary hematopoiesis (EH) is a rare but specific cutaneous manifestation of myelofibrosis with myeloid metaplasia (MMM). With the exception of hemorrhagic purpuric eruptions in neonates, EH has only been described in patients with myelofibrosis.1-5 We report herein a case of EH of the skin that differs histologically from previously described cases.
Report of a Case.—
A 67-year-old woman was seen in the hematology clinic at the University of Chicago in December 1979 for evaluation of anemia and hepatosplenomegaly. A bone core biopsy disclosed changes consistent with a diagnosis of MMM. Subsequent treatment included 100 mg/day of oral oxymetholone and several hospital admissions during which the patient received a packed RBC transfusion.In October 1981, the patient was seen in the dermatology clinic with a two-month history of asymptomatic papulonodules on the thighs and trunk. Physical examination showed firm, 5-mm erythematous nodules on the medial aspect of
Levine LE, Pearson MG, Baron JM, Medenica MM, Vardiman J. Extramedullary Hematopoiesis. Arch Dermatol. 1984;120(10):1282. doi:10.1001/archderm.1984.01650460022012