Localized epidermolysis bullosa (Weber-Cockayne syndrome), or recurrent bullous eruption of the hands and feet (RBEHF), is characterized by the early onset of recurrent blister formation on the hands and feet following frictional trauma. It is inherited in an autosomaldominant pattern. The association with hyperhidrosis and aggravation by warm weather is well known.
Based on a letter to the editor by Tkach,1 who noted improvement in a patient with RBEHF following the topical application of aluminum chloride, I instituted a similar therapeutic trial in an infant with localized epidermolysis bullosa.
Report of a Case
A 2½-year-old girl was seen in the Outpatient Dermatology Clinic at the Naval Hospital, San Diego, Calif. Her mother stated
Jennings JL. Aluminum Chloride Hexahydrate Treatment of Localized Epidermolysis Bullosa. Arch Dermatol. 1984;120(10):1382. doi:10.1001/archderm.1984.01650460122035