• Sensory neuropathies developed in three of four patients with prurigo nodularis who had been treated with thalidomide. The serum samples of the patients who had neuropathy produced morphologic changes in cultured dorsal root ganglion cells. These observed changes support the postulate that thalidomide induces primary neuronal degeneration.
(Arch Dermatol 1984;120:1466-1470)
Aronson IK, Yu R, West DP, Van Den Broek H, Antel J. Thalidomide-Induced Peripheral NeuropathyEffect of Serum Factor on Nerve Cultures. Arch Dermatol. 1984;120(11):1466-1470. doi:10.1001/archderm.1984.01650470072016