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February 1985

Phenytoin and Junctional Epidermolysis Bullosa

Author Affiliations

Department of Pediatrics Barzilai Medical Center, Ashkelon, Israel; Pediatric Dermatology Unit Beilinson Medical Center Petah Tiqva, Israel

Arch Dermatol. 1985;121(2):168-169. doi:10.1001/archderm.1985.01660020026004

To the Editor.—  We read with great interest the article by Rogers et al1 on the use of phenytoin in the treatment of junctional epidermolysis bullosa (JEB).We are in complete agreement with the authors regarding the value of this drug in treating JEB and recessive dystrophic epidermolysis bullosa (RDEB), but we have certain reservations about the dosage recommended.About a year ago we used phenytoin to treat an infant suffering from RDEB; because of the severity of his condition, we started with a full anticonvulsive dose of 7 mg/kg/day that resulted in complete recovery of all his bullae within ten days.It is our impression from reading the aforementioned article,1 as well as that in which Bauer et al2 recorded a large series of phenytoin-treated cases, that they were reluctant to start with full doses because of the possibility of side effects.As pediatricians, we are convinced

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