• Cutaneous hyperpigmentation resembling acanthosis nigricans developed in two patients with malignant brain tumors following chemotherapy with triazinate (Baker's Antifol), a folic acid antagonist. In both cases, the eruption resolved after the cessation of drug administration and reappeared after the reinstitution of triazinate therapy. A skin biopsy specimen from one patient showed microscopic changes consistent with those found in acanthosis nigricans. The other patient had a decreased serum folate level that returned to normal as the hyperpigmentation resolved. Folate may have a role in triazinate-induced acanthosislike hyperpigmentation.
(Arch Dermatol 1985;121:232-235)
Greenspan AH, Shupack JL, Foo S, Wise AC. Acanthosis Nigricans-like Hyperpigmentation Secondary to Triazinate Therapy. Arch Dermatol. 1985;121(2):232-235. doi:10.1001/archderm.1985.01660020090025