• A 51-year-old woman had a severe pustular contact hypersensitivity reaction to fluorouracil used to treat actinic keratoses on the face. The reaction was composed of long-lasting redness, facial flushing, exaggerated skin markings, and sensory changes. Physicians prescribing topical fluorouracil should be aware of its potential to produce such a severe reaction.
(Arch Dermatol 1985;121:240-242)
Sevadjian CM. Pustular Contact Hypersensitivity to Fluorouracil With Rosacealike Sequelae. Arch Dermatol. 1985;121(2):240-242. doi:10.1001/archderm.1985.01660020098027