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Article
March 1985

Metronidazole in the Treatment of Rosacea

Author Affiliations

Biol D; Department of Dermatology University of Genoa Genoa, Italy

Arch Dermatol. 1985;121(3):307-308. doi:10.1001/archderm.1985.01660030027007
Abstract

To the Editor.—  In the July issue, the hypothesis of Drs Kürkçüoğlu and Atakan1 that metronidazole's effects on rosacea may be due to the agent's antiparasitic activity against the mite Demodex folliculorum is an interesting one.While studying the survival of D folliculorum in solutions of metronidazole, we found that the mites can survive even in concentrations of as much as 1 mg/mL.2 Such levels are unlikely to occur in the skin, in view of the fact that after oral administration of 500 mg of metronidazole, the blood level reaches 15 μg/mL.3 It is to be noted, however, that metronidazole is degraded into at least five metabolites with potential biologic activity,4 among which the major urinary product, the 2-hydroxymethyl derivative, is approximately one third to ten times more active as an antibacterial agent than is metronidazole.5It may be that one or more of these

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