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March 1985

Neonatal Lupus ErythematosusA Report of Three Cases Associated With Anti-Ro/SSA Antibodies

Author Affiliations

From the Cutaneous Immunopathology Unit and the Department of Dermatology, University of Texas Health Science Center at Houston (Drs Hall, Tucker, and Jordon); and the Departments of Dermatology, Baylor College of Medicine, Houston (Dr Lumpkin), and the Gundersen Clinic, LaCrosse, Wis (Dr Hogan).

Arch Dermatol. 1985;121(3):377-381. doi:10.1001/archderm.1985.01660030099028

• Three patients had neonatal lupus erythematosus syndrome. All three infants were girls who presented with characteristic skin lesions but without evidence of congenital heart block. All three mothers were asymptomatic at the time of delivery and have remained so until the present time. All mothers were positive for anti-Ro/SSA antibodies, as were the infants prior to 6 months of age. Anti-La/SSB antibodies were not present in either the mothers or the infants. HLA typing revealed that two of the mothers were positive for B8 and DR3, while the third mother was positive for B8 and DR2. Two of the infants were positive for B8 and DR3, while the third infant was positive for DR2 only.

(Arch Dermatol 1985;121:377-381)