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April 1985

PUVA Therapy in the Treatment of Skin Lesions of the Hypereosinophilic Syndrome

Author Affiliations

Department of Dermatology Free University Hospital de Boelelaan 1117 1081 HV Amsterdam, the Netherlands

Arch Dermatol. 1985;121(4):450. doi:10.1001/archderm.1985.01660040024004

To the Editor.—  The hypereosinophilic syndrome (HES) is defined by the following criteria1: (1) A persistent eosinophil count of more than 1.5 × 109/L for longer than six months or death before six months associated with the signs and symptoms of hypereosinophilic disease; (2) a lack of evidence for parasitic, allergic, or other known causes of eosinophilia; (3) presumptive signs and symptoms of organ involvement.One of us2 previously reported a case of HES, with skin lesions as the first and, apart from blood eosinophilia, the only manifestation. We would now like to comment further on this case with regard to treatment.

Report of a Case.—  A 68-year-old man was admitted to our hospital in January 1980 with a widespread itching papular eruption of three months' duration. Prior to admission and three weeks later, he had episodes of angioedema. On those occasions, WBC count varied between

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