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Article
April 1985

Pretibial Myxedema Associated With Chronic Thyroiditis

Author Affiliations

Kitasato University School of Medicine Sagamihara, 228 Japan

Arch Dermatol. 1985;121(4):451. doi:10.1001/archderm.1985.01660040025007
Abstract

To the Editor.—  Pretibial myxedema (PM) is sometimes seen in the patients with thyroid dysfunction, most commonly Graves' disease.1 I report herein a case of pretibial myxedema that was observed in a patient with chronic lymphocytic thyroiditis.

Report of a Case.—  A 43-year-old woman was noted to have slowly growing skin eruptions on the lower part of the legs in June 1981. Physical examination revealed reddish plaques with an "orangepeellike" appearance and coarse hairs on her both legs, mild exophthalmos with periorbital edema, clubbed fingers, and diffuse goiter. Routine laboratory test results were within normal limits, except for high titer of antimicrosomal antibody. Longacting thyroid stimulator was absent. Several thyroid function tests revealed a pattern of hyperthyroidism.Histology of the skin lesion showed dense mucin deposition in the middle and lower dermis stained with toluidine blue solution, the mucin was digested with testicular hyaluronidase.A thyroid biopsy specimen revealed

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