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June 1985

Keratoacanthomas Associated With Cervical Squamous Cell Carcinoma

Author Affiliations

Creighton University School of Medicine Hereditary Cancer Institute Omaha, NE 68178

Arch Dermatol. 1985;121(6):713-714. doi:10.1001/archderm.1985.01660060025004

To the Editor.—  Inoshita and Youngberg's1 article had the following discrepancies that nullify their postulate dealing with a new syndrome (keratoacanthoma-visceral carcinoma syndrome) (1) the environmental exposure of the patient to uterine intracavitary radium implants (because of this the etiology of cervical carcinoma in this patient cannot be clearly assigned to any syndrome); (2) a lack of understanding of the heterogeneity of expression of the cancer family syndrome (CFS); and (3) inadequate genetic investigation of family members of the index patient.The extremely common carcinoma of the uterine cervix is linked etiologically to early coitus, multiple sexual partners, poor prenatal and postnatal care, and lower socioeconomic status, factors that were not considered. The etiology of the cancer in this patient was complicated by the environmental exposure of the patient to prior radiation therapy, which is an causative factor in cervical squamous cell carcinoma. Thus, this patient is not a case

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