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We identified a small but apparently distinct group of patients (consisting of three other cases in addition to our own case) who have a single female genital tract neoplasm closely associated chronologically with multiple or aggressive keratoacanthomas. The purpose of assigning a name to this association was to specifically identify it so that further cases will be recognized. Time tell if this associated group of findings will hold up as a specific entity.The comments of Drs Fusaro and Lynch concerning CFS are undoubtedly correct, but are inappropriate to our report. We were reporting a group of associated findings and did not specifically imply that we had identified a genetic syndrome. Our speculations concerning the etiology of the association included noting that the keratoacanthomas may have been a result of immunologic abnormalities seen in cancer patients (an epiphenomenon). We also compared the keratoacanthomas in our syndrome to other
Inoshita T, Youngberg GA. Keratoacanthomas Associated With Cervical Squamous Cell Carcinoma-Reply. Arch Dermatol. 1985;121(6):714. doi:10.1001/archderm.1985.01660060025005