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June 1985

Keratoacanthomas Associated With Cervical Squamous Cell Carcinoma-Reply

Author Affiliations

Department of Pathology East Tennessee State University Box 19540A Johnson City, TN 37614-0002

Arch Dermatol. 1985;121(6):714. doi:10.1001/archderm.1985.01660060025005

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In Reply.—  We identified a small but apparently distinct group of patients (consisting of three other cases in addition to our own case) who have a single female genital tract neoplasm closely associated chronologically with multiple or aggressive keratoacanthomas. The purpose of assigning a name to this association was to specifically identify it so that further cases will be recognized. Time tell if this associated group of findings will hold up as a specific entity.The comments of Drs Fusaro and Lynch concerning CFS are undoubtedly correct, but are inappropriate to our report. We were reporting a group of associated findings and did not specifically imply that we had identified a genetic syndrome. Our speculations concerning the etiology of the association included noting that the keratoacanthomas may have been a result of immunologic abnormalities seen in cancer patients (an epiphenomenon). We also compared the keratoacanthomas in our syndrome to other

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