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June 1985

Adenosquamous Carcinoma of the SkinAn Aggressive Mucin- and Gland-Forming Squamous Carcinoma

Author Affiliations

From the Departments of Pathology (Drs Weidner and Foucar) and Dermatology (Dr Foucar), University of Iowa Hospitals and Clinics, Iowa City. Dr Weidner is now with the Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.

Arch Dermatol. 1985;121(6):775-779. doi:10.1001/archderm.1985.01660060089028

• Two cases of an aggressive cutaneous carcinoma showed both squamous and adenomatous differentiation. These neoplasms invaded subcutaneous structures with a sclerosing pattern, making surgical resection difficult. Unlike the usual squamous carcinoma, glands and epithelial mucin (sialomucin) were produced. This mucin stained with mucicarmine and was sensitive to sialidase and resistant to hyaluronidase digestion. No mucin with similar histochemical properties was found in a study of 50 consecutive cutaneous squamous carcinomas and 50 consecutive basal cell epitheliomas from our files. Literature reports of histologically similar cutaneous carcinomas together with our experience with these two cases suggest aggressive behavior for this category of neoplasm.

(Arch Dermatol 1985;121:775-779)