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Article
July 1985

X-linked Inheritance of Epidermodysplasia VerruciformisGenetic and Virologic Studies of a Kindred

Author Affiliations

From the Laboratory of Cellular Oncology and Dermatology Branch, National Institutes of Health, Bethesda, Md.

Arch Dermatol. 1985;121(7):864-868. doi:10.1001/archderm.1985.01660070054014
Abstract

† We describe a family with typical epidermodysplasia verruciformis (EV) in which only male members are affected. Whereas none of the index patient's ten children have EV, four of eight grandsons born to his daughters have inherited the disorder. All are infected with human papillomavirus (HPV) 3 and HPV 8. The inheritance in this kindred most likely results from an X-linked recessive genetic defect. Since other kindreds have been described with autosomal inheritance, this novel inheritance pattern suggests that the persistent high clinical susceptibility to HPV infection characteristic of EV may result from defects in either of at least two different genetic loci, one of which may be located on the X chromosome.

(Arch Dermatol 1985;121:864-868)

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