• Hypopigmentation of hair and freckles occurred in a patient receiving chloroquine sulfate therapy. This patient had a severe congenital renal failure that presumably increased plasma and tissue levels of the drug substantially, accounting for the hypopigmentation.
(Arch Dermatol 1985;121:1164-1166)
Dupré A, Ortonne J, Viraben R, Arfeux F. Chloroquine-Induced Hypopigmentation of Hair and FrecklesAssociation With Congenital Renal Failure. Arch Dermatol. 1985;121(9):1164-1166. doi:10.1001/archderm.1985.01660090078018