• A reliable microscopic differentiation of nevomelanocytic nevi (NMNs) as congenital or acquired would be useful in defining a histogenic relationship between cutaneous melanoma and congenital NMN. In order to delineate histologic differences between congenital NMN and acquired NMN, a standardized assessment was conducted blindly, using a sample of consecutive surgical specimens of NMN submitted to a children's hospital pathology file. Despite significant histologic differences between congenital NMN and acquired NMN, the lack of a reliable prevalence rate for the proportion of congenital NMNs among all NMN specimens submitted for pathologic examination precludes a precise estimate of predictive value for diagnosing a given NMN as congenital or acquired based on histologic features alone. The results of this study can be used neither to support nor to refute a histologic association between cutaneous melanoma and congenital NMN.
(Arch Dermatol 1985;121:1266-1273)
Rhodes AR, Silverman RA, Harrist TJ, Melski JW. A Histologic Comparison of Congenital and Acquired Nevomelanocytic Nevi. Arch Dermatol. 1985;121(10):1266-1273. doi:10.1001/archderm.1985.01660100046013