A healthy male infant had been first noted to have blisters at age 36 hours. He had been the product of a full-term, uncomplicated pregnancy and vaginal delivery. His mother claimed that she had no history of herpes simplex infection, and there was no family history of blistering or other skin diseases.
At age 8 days, the patient was examined in the outpatient Dermatology Clinic and was noted to have flaccid bullae with erythematous bases on both hips (Fig 1), the lower back, the left thumb, and the lower lip. Erosions were present on the hard palate, on the left leg, and in the periungual regions of all his fingers (Fig 2). No other mucocutaneous or general medical abnormalities were noted. Bacterial cultures of the blister fluid were negative.
A biopsy specimen was taken from skin adjacent to a blister on the right flank; routine histopathologic examination disclosed a separation
Pfau RG, Patel HP, Cohen BA, Watson R. Blistering Eruption in Healthy Newborns. Arch Dermatol. 1986;122(2):211-212. doi:10.1001/archderm.1986.01660140101028