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May 1986

Evidence for HTLV-I Associated With Mycosis Fungoides and B-Cell Chronic Lymphocytic Leukemia

Author Affiliations

From the Departments of Dermatology (Drs Peterman and Jerdan) and Oncology (Dr Staal), The Johns Hopkins Medical Institutions, Baltimore; the Clinical Immunology Section, Gerontology Research Center, National Institute on Aging, Baltimore (Dr Bender); the Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Md (Drs Striecher and Schüpbach); and the Department of Dermatology, Mount Sinai Medical Center, Miami Beach, Fla (Dr Resnick).

Arch Dermatol. 1986;122(5):568-571. doi:10.1001/archderm.1986.01660170098028

• Human T-cell lymphotropic virus type I (HTLV-I) is a human retrovirus that can transform T-helper lymphocytes and is etiologically associated with adult T-cell lymphoma/leukemia. Mycosis fungoides represents a primary cutaneous lymphoma of helper T-cell origin, while chronic lymphocytic leukemia is generally considered to be a neoplastic B-lymphocyte disorder. Our patient had HTLV-I with coexistent mycosis fungoides and B-cell chronic lymphocytic leukemia. The concurrent lymphoid proliferations may represent HTLV-I-associated abnormalities of immunoregulation.

(Arch Dermatol 1986;122:568-571)