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May 1986

Multiple Hamartoma Syndrome (Cowden's Disease) Associated With Non-Hodgkin's Lymphoma

Author Affiliations


From the Dermatology Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC (Drs Elston, James, and Rodman); and the Department of Medicine, Duke University Medical Center, Durham, NC (Dr Graham).

Arch Dermatol. 1986;122(5):572-575. doi:10.1001/archderm.1986.01660170102029

• A 70-year-old woman with the multiple hamartoma syndrome is described. Diagnosis was based on the clinical presentation and histopathologic examination of cutaneous trichilemmomas. The case is reported to document the association of Cowden's disease with non-Hodgkin's lymphoma. This is the first known report of the occurrence of trichilemmomas in the sacral area. The literature concerning the association of the multiple hamartoma syndrome with malignancy is reviewed.

(Arch Dermatol 1986;122:572-575)