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May 1986

Pseudomembranous Colitis Caused by Topical Clindamycin Phosphate

Author Affiliations

From the Departments of Medicine and Surgery, St Joseph Hospital, Stamford, Conn (Drs Parry and Rha); the Department of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York (Dr Parry), and the Department of Surgery, New York Medical College, Valhalla (Dr Rha).

Arch Dermatol. 1986;122(5):583-584. doi:10.1001/archderm.1986.01660170113031

• Pseudomembranous colitis was observed on two occasions in the same patient and was associated with the topical administration of clindamycin phosphate. Assay for Clostridium difficile toxin was positive, and the patient was ultimately cured by oral vancomycin hydrochloride and the withdrawal of clindamycin therapy.

(Arch Dermatol 1986;122:583-584)