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June 1986

Immunologic Abnormalities in Linear Scleroderma

Author Affiliations

Department of Dermatology Hospital Clínico San Carlos 28040 Madrid, Spain

Arch Dermatol. 1986;122(6):623-624. doi:10.1001/archderm.1986.01660180023003

To the Editor.—  In the November 1985 issue of the Archives, Woo et al1 reported the results of their serologic study in linear scleroderma. Previously, Falanga et al2 reported high titers of antibodies to single-stranded DNA in this disease. We have had a related case in our department, with some findings that we consider important to communicate.The patient was a 21-year-old woman who developed linear scleroderma in the right leg during pregnancy. Before the sclerosis could be appreciated, she showed a pruritic, papuloerythematous eruption, in a similar way to the case reported by Siegel.3 In less than five months, all of the leg—from the inguinal region to the dorsal region of the foot—was affected in a linear arrangement with polymorphic lesions (indurated patches, hyperpigmented depressed areas, and erythematous patches). Histologic examination was consistent with scleroderma. Immunoglobulin deposit was not detected in affected skin.We have followed

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