• The HLA type of patients with various kinds of immune reactions to bovine collagen implants were evaluated to determine a possible genetic basis for such responses. All patients suffering adverse clinical reactions to bovine collagen implants were lacking the HLA-DR4 antigen. All patients who received multiple bovine collagen injections without having adverse clinical reactions were lacking HLA-B5 and HLA-DR5 and had a significantly increased incidence of HLA-DR4. Combinations of histocompatibility antigens may influence immune response to bovine collagen implants.
(Arch Dermatol 1986;122:650-654)
Vanderveen EE, McCoy JP, Schade W, Kapur JJ, Hamilton T, Ragsdale C, Grekin RC, Swanson NA. The Association of HLA and Immune Responses to Bovine Collagen Implants. Arch Dermatol. 1986;122(6):650-654. doi:10.1001/archderm.1986.01660180056014