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July 1986

Successful Treatment of Condylomata Acuminata and Bowenoid Papulosis With Subcutaneous Injections of Low-Dose Recombinant Interferon-a

Author Affiliations

Department of Dermatology University of Freiburg Hauptstrasse 7 D-7800 Freiburg Federal Republic of Germany; German Cancer Research Center Heidelberg D-6900 Heidelberg Federal Republic of Germany; Dr Karl Thomae GmbH D-7950 Biberach/Riss Federal Republic of Germany

Arch Dermatol. 1986;122(7):749-750. doi:10.1001/archderm.1986.01660190025008

To the Editor.—  Treatment of genitoanal papillomavirus-associated lesions has been shown to be rather difficult. Condylomata acuminata of the urethral and anorectal mucosae especially remain a therapeutic problem. Surgical methods that include electrosurgery, cryosurgery, or even laser surgery are seldom devoid of side effects, such as associated pains or formation of scars at the treated site. Relapses are seen in up to 39% of the cases treated with conventional surgical methods.1 Bowenoid papulosis (BP), a peculiar disease that could have been contributed only very recently to the list of human papillomavirus (HPV)-associated lesions,2 thus far was regarded as untreatable by noninvasive means. Bowenoid papulosis lesions that are situated on the anogenital skin and mucosae consist of flat, slightly pigmented papules or even leukoplakialike efflorescences.2 These lesions, though clinically exhibiting very unsuspicious maculae, papulae, or plaques, histologically represent carcinomata in situ that harbor HPV-16 regularly.2,3 DNA sequences

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