• The ability of topically applied betamethasone valerate to reduce erythema produced by a variety of vasodilators was assessed. The steroid significantly reduced the erythema induced by topical arachidonic acid, intradermal histamine, and compound 48/80. We postulated that the steroid reduced endogenous phospholipase activity either before or after application of the vasodilators, or both. This action may explain the mechanism of glucocorticoid-induced vasoconstriction in the skin and part of the steroids' action in acute inflammatory skin disease.
(Arch Dermatol 1986;122:881-883)
Marks R, Sawyer M. Glucocorticoid-Induced Vasoconstriction in Human SkinAn Inhibitory Role on Phospholipase A2 Activity. Arch Dermatol. 1986;122(8):881-883. doi:10.1001/archderm.1986.01660200053013