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Article
September 1986

Histiocytosis X

Author Affiliations

Hôpital de Bavière B-4020 Liège, Belgium

Arch Dermatol. 1986;122(9):973. doi:10.1001/archderm.1986.01660210021006
Abstract

To the Editor.—  Regarding the study presented by Goldberg et al1 about the proliferative activity of histiocytosis X cells and the editorial by Scarpelli2 in the April issue of the Archives, we would like to describe our previously published observation.3 By using autoradiography after injection of tritiated thymidine, we presented evidence in a patient with Hand-Schüller-Christian disease that a large number of histiocytosis X cells were proliferating in the skin.Following that report, we have now made double labelings proving that a vast majority of cells in S phase contained the S100 protein. The number of histiocytosis X cells in S phase in our patient was much higher than the moderate increase reported by Goldberg et al in their estimation by flow cytometry of the proportion of cells in the various phases of the cell cycle. However, as Goldberg et al stated, they may have considerably underestimated

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