• We describe a patient who developed hyperkeratotic, verrucous plaques at sites of repeated insulin injections. One similar case has previously been reported. This phenomenon may be an unusual manifestation of the trophic actions of insulin.
(Arch Dermatol: 122:1054-1056)
Fleming MG, Simon SI. Cutaneous Insulin Reaction Resembling Acanthosis Nigricans. Arch Dermatol. 1986;122(9):1054–1056. doi:10.1001/archderm.1986.01660210104028