To the Editor.—
The development of multiple seborrheic keratoses in a patient with an associated internal malignancy has been referred to as the sign of Leser-Trélat. This condition is almost always diagnosed in elderly people who have an underlying adenocarcinoma, usually of the gastrointestinal tract. We present the rare occurrence of multiple eruptive seborrheic keratoses in a 22-year-old man who had an intracranial tumor. The significance of this case is discussed herein with respect to the validity of the sign of Leser-Trélat.
Report of a Case.—
A 22-year-old man presented to the Letterman Army Medical Center, San Francisco, in August 1984, with persistent headaches, diplopia, and bilateral papilledema. Results of a computed tomographic scan revealed enlarged lateral and third ventricles, as well as an enlarged calcified pineal body. Results of a subsequent nuclear magnetic resonance study confirmed these findings and were suggestive of a germinoma. The α1-fetoprotein level was 22
Westrom DR, Berger TG. The Sign of Leser-Trélat in a Young Man. Arch Dermatol. 1986;122(12):1356-1357. doi:10.1001/archderm.1986.01660240018004