• A 3-month-old infant with scleredema had associated cytomegalovirus pneumonia with a rapidly fatal course. Because differentiation of scleredema from sclerema neonatorum, subcutaneous fat necrosis, and scleroderma may be difficult, histologic diagnosis is important. Cetylpyridinium chloride was used successfully as a fixative to demonstrate acid mucopolysaccharides histologically.
(Arch Dermatol 1986;122:1417-1419)
Heilbron B, Saxe N. Scleredema in an Infant. Arch Dermatol. 1986;122(12):1417-1419. doi:10.1001/archderm.1986.01660240081022